PUBLICATIONS
Bouhaddou Lab Publications
November 14, 2025
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November 3, 2025
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June 7, 2025
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December 20, 2024
Led by Jocelyn Ni and Prashant Kaushal, we perform deep phosphoproteomics analysis of JLat 10.6 cells stimulated with SAHA, prostratin, and PMA, finding convergent phosphoregualtion of nuclear protein complexes, which may mechanistically impinge on latency reversal.
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Led by Kareem Alba and Declan Winters, we use The Kinase Library to globally map human kinase motifs in viral 1,505 virus proteomes. These motifs are enriched for stress, immune, and cell cycle kinases, suggesting viruses have evolved to sense and biochemically respond to these signaling pathways.
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Led by Charles Olwal, we integrated patient-derived RNA-seq and proteomic/ phosphoproteomic analyses of cultured cells revealed that HIV-1-infected T-cell paracrine signaling dysregulates core cervical cell-cycle pathways, including MAPK/ERK and PI3K.
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Led by Prashant Kaushal and in collaboration with the Krogan Lab, in this protocol, we describe how to quantitatively compare protein-protein interactions, using affinity purification mass spectrometry (AP-MS), between two conditions, be they different bait proteins, different stimulus conditions, or cellular contexts.​​​​​​
Collaborative Bouhaddou Lab Publications
November 17, 2025
Parks K, Jhawar A, Andrikopoulos A, Winters DM, Dean TS, Kapelczak ED, TeSlaa T, Bouhaddou M, Schmitt DL. Spatial regulation of AMPK activity under oxidative stress requires LKB1. bioRxiv.
October 28, 2025
Alvarez PA, Tang A, Winters DM, Kaushal P, Medina A, Nieto MV, Kaczor-Urbanowicz KE, St Amant F, Reyes BR, Kaake RM, Fregoso OI, Pyle AD, Bouhaddou M, Tang H, Li MMH. Old World alphaviruses use distinct mechanisms to infect brain microvascular endothelial cells for neuroinvasion. Cell Rep.
October 14, 2025
Wang B, Tran MN, Wang S, Liu Y, Olfson E, Wang G, Sun N, Dea J, Olwal CO, Bertolace L, Bloch MH, Cappi C, Chang YC, Chavira D, Coffey BJ, Falkenstein MJ, Frank AC, Franklin ME, Garayalde S, Garrido H, Grados M, Hatem R, Howell AL, Khim S, Kuckertz JM, Le MM, Libby A, McCarty RJ, McNamara ME, McNeil D, Miguel EC, Nasello C, Nguyen B, Norbu T, Oh L, Ordway A, Paciotti C, Peskin VA, Pittenger C, Simpson HB, Martin HS, Tischfield MA, Xing J, Zakrzewski JJ, Tourette International Collaborative Genetics (TIC Genetics), Dietrich A, Gilbert DL, Hoekstra PJ, Kim YS, Kuperman S, Rosen A, Zinner SH, Bouhaddou M, King RA, Rouleau G, Ressler KJ, Mathews CA, Krogan NJ, Sestan N, Tischfield JA, Lee AM, Heiman GA, Fernandez TV, Willsey AJ, State MW. Rare coding mutations identify 36 large-effect risk genes in obsessive-compulsive disorder and chronic tic disorders. medRxiv.
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August 28, 2025
Yao Z, Alvarez PA, Chavez C, Delgado Y, Kaushal P, Austin D, Li Q, Yu Y, Zaiss AK, Arumugaswami V, Ding Q, Hsu JJ, Damoiseaux R, Bouhaddou M, Hoffmann A, Li MMH. SARS-CoV-2 nucleocapsid induces hyperinflammation and vascular leakage through the Toll-like receptor signaling axis in macrophages. bioRxiv.
July 28, 2025
Batra J, Rutkowska M, Zhou Y, Ye C, Adavikolanu R, Young JM, Anand D, Verma S, Gordon M, Malpotra S, Cupic A, Kehrer T, Moen JM, Winters DM, Rojc A, Mena I, Aslam S, Martinez-Romero C, Conde Viñas I, Khalil Z, Farrugia K, Banerjee A, Tussia-Cohen D, Santos MD, Maji S, Muralidharan M, Foussard H, Chen IP, Fuchs R, Felipe CS, Zuliani-Alvarez L, Choudhury P, Obernier K, Gracias S, Suryawanshi R, Ibáñez C, Juste J, Pache L, Taha TY, Jouvenet N, Verba KA, Fraser JS, Demeret C, Stroud RM, van Bakel H, Ott M, Hagai T, Polacco B, Swaney DL, Echeverria I, Bouhaddou M, Eckhardt M, Malik HS, Martinez-Sobrido L, Miorin L, García-Sastre A, Krogan NJ. Coronavirus protein interaction mapping in bat and human cells identifies molecular and genetic switches for immune evasion and replication. bioRxiv.
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July 2, 2025
Durra A, Cherry C, Luo C, Hou E, Frauenpreis A, Purkayastha A, Passamano I, Makanani S, Castillo K, Lund A, Choi W, Sen C, Chandran R, Rickabaugh T, Kaushal P, Bouhaddou M, Vladar EK, Gomperts BN. Unflavored electronic cigarette exposure induces alterations in airway ciliary structure and function. Respir Res.
June 6, 2025
Nisson KA, Patel RS, Delgado Y, Bouhaddou M, Etienne L, Fregoso OI. HIV Vpr activates a nucleolar-specific ATR pathway to degrade the nucleolar stress sensor CCDC137. Nucleic Acids Res.
May 5, 2025
Jeyachandran AV, Zaiss AK, Chakravarty N, Singh S, Delgado Y, Paravastu R, Satheeshkumar N, Gerald E, Jeysankar A, Thomas J, Fuller L, Lee N, Taylor C, Joshi S, Parcells M, French SW, Date A, Bouhaddou M, Garcia G Jr, Kumar A, Damoiseaux R, Arumugaswami V. Drug screen reveals new potent host-targeted antivirals against Mpox virus. Res Sq.
October 15, 2024
Yao Z, Ramachandran S, Huang S, Kim E, Jami-Alahmadi Y, Kaushal P, Bouhaddou M, Wohlschlegel JA, Li MM. Interaction of chikungunya virus glycoproteins with macrophage factors controls virion production. EMBO J.
September 26, 2024
Ryu JK, Yan Z, Montano M, Sozmen EG, Dixit K, Suryawanshi RK, Matsui Y, Helmy E, Kaushal P, Makanani SK, Deerinck TJ, Meyer-Franke A, Rios Coronado PE, Trevino TN, Shin MG, Tognatta R, Liu Y, Schuck R, Le L, Miyajima H, Mendiola AS, Arun N, Guo B, Taha TY, Agrawal A, MacDonald E, Aries O, Yan A, Weaver O, Petersen MA, Meza Acevedo R, Alzamora MDPS, Thomas R, Traglia M, Kouznetsova VL, Tsigelny IF, Pico AR, Red-Horse K, Ellisman MH, Krogan NJ, Bouhaddou M, Ott M, Greene WC, Akassoglou K. Fibrin drives thromboinflammation and neuropathology in COVID-19. Nature.
In collaboration with the lab of Danielle Schmitt and first author Kasey Parks (UCLA), this work probes compartment-specific AMPK dynamics in response to oxidative stress using sub-cellular fluorescent biosensors. Declan Winters in our lab did phosphoproteomics to characterize AMPK phosphorylation and substrates.
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In collaboration with the lab of Melody Li and first author Pablo Alvarez (UCLA), this work showed that neuroinvasive alphaviruses directly infect human pluripotent stem cell–derived blood brain barrier cells. Declan Winters and Prashant Kaushal from our lab performed biotinylation-based cell surface proteomics to identify candidate viral entry receptors.
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In collaboration with Matthew State, Nevan Krogan, and first author Belinda Wang (UCSF), this paper links rare coding variants to obsessive compulsive disorder and chronic tic disorders. Charles Olwal from our lab used bioinformatics to understand pathway-level convergence between these and other gene sets linked to neurological conditions.
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In collaboration with the lab of Melody Li and first author Zhenlan Yao (UCLA), this work found the SARS-CoV-2 nucleocapsid protein induced hyperinflammation when expressed in macrophages, with Delta variant N inducing the most pro-inflammatory activation. Yennifer Delgado and Prashant Kaushal performed affinity purification mass spectrometry (AP-MS) of distinct variant N forms in macrophages to study the mechanism of action.
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In collaboration with the lab of Nevan Krogan and first author Jyoti Batra (UCSF), this work quantitatively compared SARS-CoV-2-host and RatG13-host protein-protein interactions in bat and human cells, discovering bat-specific virus-host interactions that may underlie immune evasion and host adaptation. Declan Winters from our lab performed an elegant network propagation-based analysis to identify shared and divergent pathways hijacked by SARS-CoV-2 and RatG13.
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In collaboration with the lab of Brigitte Gomperts and first author Abdo Durra (UCLA), this work showed that electronic cigarette exposure disrupts cilia function and signaling in air-liquid interface (ALI) primary epithelial cultures. Prashant Kaushal from our lab performed abundance proteomics and phosphoproteomics to define affected signaling pathways.
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In collaboration with the lab of Oliver Fregoso (UCSC) and first author Karly Nisson (UCLA), this study showed that HIV-1 Vpr activates nucleolar stress via CCDC137. Yennifer Delgado from our lab performed integrative bioinformatics pathway analysis combining this study with publicly available datasets to specify Vpr-affected pathways.
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In collaboration with the lab of Vaithi Arumugaswami and first author Arjit Jeyachandran (UCLA), this study identified novel host-targeted antivirals against Mpox, with Yennifer Delgado from our lab performing and analyzing multi-omics data.
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In collaboration with the lab of Melody Li and first author Zhenlan Yao (UCLA), this study found interactions between chikungunya glycoproteins with host proteins in macrophage control virion production. Prashant Kaushal from our lab created a network representation of the protein-protein interaction data collected by James Wohlschlegel by integrating CORUM protein complex information.
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In collaboration with the lab of Katerina Akassoglou and first author Jae Kyu (Gladstone Institutes), this study established that fibrin drives thromboinflammation and neuropathology in COVID-19. Sara Makanani and Prashant Kaushal from our lab performed phosphoproteomics of fibrin-treated human natural killer (NK) cells to define downstream signaling pathways.
Selected Publications from Mehdi's Postdoc and PhD
February 3, 2025
Mohammed AM, Olwal CO, Fossati A, Nyakoe NK, Fabius JM, Gordon M, Polacco BJ, Swaney DL, Awandare GA, Krogan NJ, Bouhaddou M, Bediako Y. Malaria exposure remodels the plasma proteome of Ghanaian children. BMC Infect Dis.
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November 21, 2024
Syed AM, Ciling A, Chen IP, Carlson CR, Adly AN, Martin HS, Taha TY, Khalid MM, Price N, Bouhaddou M, Ummadi MR, Moen JM, Krogan NJ, Morgan DO, Ott M, Doudna JA. SARS-CoV-2 evolution balances conflicting roles of N protein phosphorylation. PLoS Pathog.
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April 10, 2024
Rathore U, Haas P, Easwar Kumar V, Hiatt J, Haas KM, Bouhaddou M, Swaney DL, Stevenson E, Zuliani-Alvarez L, McGregor MJ, Turner-Groth A, Ochieng’ Olwal C, Bediako Y, Braberg H, Soucheray M, Ott M, Eckhardt M, Hultquist JF, Marson A, Kaake RM, Krogan NJ. CRISPR-Cas9 screen of E3 ubiquitin ligases identifies TRAF2 and UHRF1 as regulators of HIV latency in primary human T cells. mBio.
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October 11, 2023
Kehrer T, Cupic A, Ye C, Yildiz S, Bouhaddou M, Crossland NA, Barrall EA, Cohen P, Tseng A, ÇaÄŸatay T, Rathnasinghe R, Flores D, Jangra S, Alam F, Mena I, Aslam S, Saqi A, Rutkowska M, Ummadi MR, Pisanelli G, Richardson RB, Veit EC, Fabius JM, Soucheray M, Polacco BJ, Ak B, Marin A, Evans MJ, Swaney DL, Gonzalez-Reiche AS, Sordillo EM, van Bakel H, Simon V, Zuliani-Alvarez L, Fontoura BMA, Rosenberg BR, Krogan NJ, Martinez-Sobrido L, García-Sastre A, Miorin L. Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis. Cell Host Microbe.
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October 12, 2023
Bouhaddou M, Reuschl AK, Polacco BJ, Thorne LG, Ummadi MR, Ye C, Rosales R, Pelin A, Batra J, Jang GM, Xu J, Moen JM, Richards AL, Zhou Y, Harjai B, Stevenson E, Rojc A, Ragazzini R, Whelan MVX, Furnon W, De Lorenzo G, Cowton V, Syed AM, Ciling A, Deutsch N, Pirak D, Dowgier G, Mesner D, Turner JL, McGovern BL, Rodriguez ML, Leiva-Rebollo R, Dunham AS, Zhong X, Eckhardt M, Fossati A, Liotta NF, Kehrer T, Cupic A, Rutkowska M, Mena I, Aslam S, Hoffert A, Foussard H, Olwal CO, Huang W, Zwaka T, Pham J, Lyons M, Donohue L, Griffin A, Nugent R, Holden K, Deans R, Aviles P, Lopez-Martin JA, Jimeno JM, Obernier K, Fabius JM, Soucheray M, Hüttenhain R, Jungreis I, Kellis M, Echeverria I, Verba K, Bonfanti P, Beltrao P, Sharan R, Doudna JA, Martinez-Sobrido L, Patel AH, Palmarini M, Miorin L, White K, Swaney DL, Garcia-Sastre A, Jolly C, Zuliani-Alvarez L, Towers GJ, Krogan NJ. SARS-CoV-2 variants evolve convergent strategies to remodel the host response. Cell.
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September 27, 2023
Haas KM, McGregor MJ, Bouhaddou M, Polacco BJ, Kim EY, Nguyen TT, Newton BW, Urbanowski M, Kim H, Williams MAP, Rezelj VV, Hardy A, Fossati A, Stevenson EJ, Sukerman E, Kim T, Penugonda S, Moreno E, Braberg H, Zhou Y, Metreveli G, Harjai B, Tummino TA, Melnyk JE, Soucheray M, Batra J, Pache L, Martin-Sancho L, Carlson-Stevermer J, Jureka AS, Basler CF, Shokat KM, Shoichet BK, Shriver LP, Johnson JR, Shaw ML, Chanda SK, Roden DM, Carter TC, Kottyan LC, Chisholm RL, Pacheco JA, Smith ME, Schrodi SJ, Albrecht RA, Vignuzzi M, Zuliani-Alvarez L, Swaney DL, Eckhardt M, Wolinsky SM, White KM, Hultquist JF, Kaake RM, García-Sastre A, Krogan NJ. Proteomic and genetic analyses of influenza A viruses identify pan-viral host targets. Nat Commun.
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August 14, 2023
Olwal CO, Fabius JM, Zuliani-Alvarez L, Eckhardt M, Kyei GB, Quashie PK, Krogan NJ, Bouhaddou M, Bediako Y. Network modeling suggests HIV infection phenocopies PI3K-AKT pathway mutations to enhance HPV-associated cervical cancer. Mol Omics.
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June 8, 2023
Mendiola AS, Yan Z, Dixit K, Johnson JR, Bouhaddou M, Meyer-Franke A, Shin MG, Yong Y, Agrawal A, MacDonald E, Muthukumar G, Pearce C, Arun N, Cabriga B, Meza-Acevedo R, Alzamora MDPS, Zamvil SS, Pico AR, Ryu JK, Krogan NJ, Akassoglou K. Defining blood-induced microglia functions in neurodegeneration through multiomic profiling. Nat Immunol.
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April 1, 2022
Hiatt J, Hultquist JF, McGregor MJ, Bouhaddou M, Leenay RT, Simons LM, Young JM, Haas P, Roth TL, Tobin V, Wojcechowskyj JA, Woo JM, Rathore U, Cavero DA, Shifrut E, Nguyen TT, Haas KM, Malik HS, Doudna JA, May AP, Marson A, Krogan NJ. A functional map of HIV-host interactions in primary human T cells. Nat Commun.
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February 2022
Thorne LG, Bouhaddou M, Reuschl AK, Zuliani-Alvarez L, Polacco B, Pelin A, Batra J, Whelan MVX, Hosmillo M, Fossati A, Ragazzini R, Jungreis I, Ummadi M, Rojc A, Turner J, Bischof ML, Obernier K, Braberg H, Soucheray M, Richards A, Chen KH, Harjai B, Memon D, Hiatt J, Rosales R, McGovern BL, Jahun A, Fabius JM, White K, Goodfellow IG, Takeuchi Y, Bonfanti P, Shokat K, Jura N, Verba K, Noursadeghi M, Beltrao P, Kellis M, Swaney DL, García-Sastre A, Jolly C, Towers GJ, Krogan NJ. Evolution of enhanced innate immune evasion by SARS-CoV-2. Nature.
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October 22, 2021
Bouhaddou M, Lee RH, Li H, Bhola NE, O’Keefe RA, Naser M, Zhu TR, Nwachuku K, Duvvuri U, Olshen AB, Roy R, Hechmer A, Bolen J, Keysar SB, Jimeno A, Mills GB, Vandenberg S, Swaney DL, Johnson DE, Krogan NJ, Grandis JR. Caveolin-1 and Sox-2 are predictive biomarkers of cetuximab response in head and neck cancer. JCI Insight.
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October 1, 2021
Kim M, Park J, Bouhaddou M, Kim K, Rojc A, Modak M, Soucheray M, McGregor MJ, O’Leary P, Wolf D, Stevenson E, Foo TK, Mitchell D, Herrington KA, Muñoz DP, Tutuncuoglu B, Chen KH, Zheng F, Kreisberg JF, Diolaiti ME, Gordan JD, Coppé JP, Swaney DL, Xia B, van ’t Veer L, Ashworth A, Ideker T, Krogan NJ. A protein interaction landscape of breast cancer. Science.
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February 26, 2021
White KM, Rosales R, Yildiz S, Kehrer T, Miorin L, Moreno E, Jangra S, Uccellini MB, Rathnasinghe R, Coughlan L, Martinez-Romero C, Batra J, Rojc A, Bouhaddou M, Fabius JM, Obernier K, Dejosez M, Guillén MJ, Losada A, Avilés P, Schotsaert M, Zwaka T, Vignuzzi M, Shokat KM, Krogan NJ, García-Sastre A. Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A. Science.
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December 4, 2020
Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, Kaake RM, Weckstein AR, Owens TW, Gupta M, Pourmal S, Titus EW, Cakir M, Soucheray M, McGregor M, Cakir Z, Jang G, O’Meara MJ, Tummino TA, Zhang Z, Foussard H, Rojc A, Zhou Y, Kuchenov D, Hüttenhain R, Xu J, Eckhardt M, Swaney DL, Fabius JM, Ummadi M, Tutuncuoglu B, Rathore U, Modak M, Haas P, Haas KM, Naing ZZC, Pulido EH, Shi Y, Barrio-Hernandez I, Memon D, Petsalaki E, Dunham A, Marrero MC, Burke D, Koh C, Vallet T, Silvas JA, Azumaya CM, Billesbølle C, Brilot AF, Campbell MG, Diallo A, Dickinson MS, Diwanji D, Herrera N, Hoppe N, Kratochvil HT, Liu Y, Merz GE, Moritz M, Nguyen HC, Nowotny C, Puchades C, Rizo AN, Schulze-Gahmen U, Smith AM, Sun M, Young ID, Zhao J, Asarnow D, Biel J, Bowen A, Braxton JR, Chen J, Chio CM, Chio US, Deshpande I, Doan L, Faust B, Flores S, Jin M, Kim K, Lam VL, Li F, Li J, Li YL, Li Y, Liu X, Lo M, Lopez KE, Melo AA, Moss FR 3rd, Nguyen P, Paulino J, Pawar KI, Peters JK, Pospiech TH Jr, Safari M, Sangwan S, Schaefer K, Thomas PV, Thwin AC, Trenker R, Tse E, Tsui TKM, Wang F, Whitis N, Yu Z, Zhang K, Zhang Y, Zhou F, Saltzberg D, QCRG Structural Biology Consortium, Hodder AJ, Shun-Shion AS, Williams DM, White KM, Rosales R, Kehrer T, Miorin L, Moreno E, Patel AH, Rihn S, Khalid MM, Vallejo-Gracia A, Fozouni P, Simoneau CR, Roth TL, Wu D, Karim MA, Ghoussaini M, Dunham I, Berardi F, Weigang S, Chazal M, Park J, Logue J, McGrath M, Weston S, Haupt R, Hastie CJ, Elliott M, Brown F, Burness KA, Reid E, Dorward M, Johnson C, Wilkinson SG, Geyer A, Giesel DM, Baillie C, Raggett S, Leech H, Toth R, Goodman N, Keough KC, Lind AL, Zoonomia Consortium, Klesh RJ, Hemphill KR, Carlson-Stevermer J, Oki J, Holden K, Maures T, Pollard KS, Sali A, Agard DA, Cheng Y, Fraser JS, Frost A, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Alessi DR, Davies P, Frieman MB, Ideker T, Abate C, Jouvenet N, Kochs G, Shoichet B, Ott M, Palmarini M, Shokat KM, García-Sastre A, Rassen JA, Grosse R, Rosenberg OS, Verba KA, Basler CF, Vignuzzi M, Peden AA, Beltrao P, Krogan NJ. Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science.
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August 6, 2020
Bouhaddou M, Memon D, Meyer B, White KM, Rezelj VV, Correa Marrero M, Polacco BJ, Melnyk JE, Ulferts S, Kaake RM, Batra J, Richards AL, Stevenson E, Gordon DE, Rojc A, Obernier K, Fabius JM, Soucheray M, Miorin L, Moreno E, Koh C, Tran QD, Hardy A, Robinot R, Vallet T, Nilsson-Payant BE, Hernandez-Armenta C, Dunham A, Weigang S, Knerr J, Modak M, Quintero D, Zhou Y, Dugourd A, Valdeolivas A, Patil T, Li Q, Hüttenhain R, Cakir M, Muralidharan M, Kim M, Jang G, Tutuncuoglu B, Hiatt J, Guo JZ, Xu J, Bouhaddou S, Mathy CJP, Gaulton A, Manners EJ, Félix E, Shi Y, Goff M, Lim JK, McBride T, O’Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, De Wit E, Leach AR, Kortemme T, Shoichet B, Ott M, Saez-Rodriguez J, tenOever BR, Mullins RD, Fischer ER, Kochs G, Grosse R, García-Sastre A, Vignuzzi M, Johnson JR, Shokat KM, Swaney DL, Beltrao P, Krogan NJ. The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Cell.
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July 16, 2020
Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O’Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Mac Kain A, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Shen W, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Rakesh R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang XP, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O’Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu-Ozturk D, Wang HY, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d’Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor SN, Fraser JS, Gross JD, Sali A, Roth BL, Ruggero D, Taunton J, Kortemme T, Beltrao P, Vignuzzi M, García-Sastre A, Shokat KM, Shoichet BK, Krogan NJ. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature.
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March 26, 2018
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November 30, 2016
Bouhaddou M, DiStefano MS, Riesel EA, Carrasco E, Holzapfel HY, Jones DC, Smith GR, Stern AD, Somani SS, Thompson TV, Birtwistle MR. Drug response consistency in CCLE and CGP. Nature.
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April 7, 2014
Bouhaddou M, Birtwistle MR. Dimerization-based control of cooperativity. Mol Biosyst.
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